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1

Sonification of numerical data for education

Vines, Karen, Hughes, Chris, Alexander, Laura, Calvert, Carol, Colwell, Chetz, Holmes, Hilary, Kotecki, Claire, Parks, Kaela, Pearson, Victoria

Journal:

Open Learning / The Journal of Open and Distance Learning

Year:

2019

Language:

english

File:

PDF, 1.93 MB

english, 2019

2

A single-sample assay for the estimation of the area under the free carboplatin plasma concentration versus time curve

Saad Ghazal-Aswad, A. Hilary Calvert, David R. Newell

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.68 MB

english, 1996

3

Endpoints and other considerations in phase I studies of targeted anticancer therapy: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies (MDICT)

Christopher M. Booth, A. Hilary Calvert, Giuseppe Giaccone, Marinus W. Lobbezoo, Lesley K. Seymour, Elizabeth A. Eisenhauer

Journal:

European Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 151 KB

english, 2008

4

Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies

Seymour, Lesley K., Calvert, A. Hilary, Lobbezoo, Marinus W., Eisenhauer, Elizabeth A., Giaccone, Giuseppe

Journal:

European Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 243 KB

english, 2013

5

Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial

Krug, Lee M, Kindler, Hedy L, Calvert, Hilary, Manegold, Christian, Tsao, Anne S, Fennell, Dean, Öhman, Ronny, Plummer, Ruth, Eberhardt, Wilfried E E, Fukuoka, Kazuya, Gaafar, Rabab M, Lafitte, Jean-J

Journal:

The Lancet Oncology

Year:

2015

Language:

english

File:

PDF, 481 KB

english, 2015

6

The clinical development of carboplatin – A personal perspective

Calvert, Hilary

Journal:

Inorganica Chimica Acta

Year:

2019

Language:

english

File:

PDF, 222 KB

english, 2019

7

ChemInform Abstract: Resistance-Modifying Agents. Part 7. 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that Inhibit Nucleoside Transport in the Presence of α1-Acid Glycoprotein (AGP).

Hannah C. Barlow, Karen J. Bowman, Nicola J. Curtin, A. Hilary Calvert, Bernard T. Golding, Bing Huang, Peter J. Loughlin, David R. Newell, Peter G. Smith, Roger J. Griffin

Journal:

Year:

2000

Language:

english

File:

PDF, 41 KB

english, 2000

8

Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins, A. Hilary Calvert, Nicola J. Curtin, Gillian Farnie, Bernard T. Golding, Roger J. Griffin, Sabrina Guyenne, Claire Hutton, Per Källblad, Stuart J. Kem

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 221 KB

english, 2005

9

Analysis of total and organic carbon and total nitrogen in settling oceanic particles and a marine sediment: an interlaboratory comparison

Penny King, Hilary Kennedy, Philip P Newton, Timothy D Jickells, Timothy Brand, Stephen Calvert, Gustave Cauwet, Henri Etcheber, Bob Head, Alexis Khripounoff, Barbara Manighetti, Juan Carlos Miquel

Journal:

Marine Chemistry

Year:

1998

Language:

english

File:

PDF, 154 KB

english, 1998

10

Determination of the anthrapyrazole anticancer drug CI-941 in plasma and urine by solid-phase extraction and high-performance liquid chromatography

Martin A. Graham, David R. Newell, A. Hilary Calvert

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1989

Language:

english

File:

PDF, 530 KB

english, 1989

11

Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

Hannah C Barlow, Karen J Bowman, Nicola J Curtin, A.Hilary Calvert, Bernard T Golding, Bing Huang, Peter J Loughlin, David R Newell, Peter G Smith, Roger J Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 134 KB

english, 2000

12

Structure-Based design of 2-Arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-Dependent kinases 1 and 2

Kerry L. Sayle, Johanne Bentley, F.Thomas Boyle, A.Hilary Calvert, Yuzhu Cheng, Nicola J. Curtin, Jane A. Endicott, Bernard T. Golding, Ian R. Hardcastle, Philip Jewsbury, Veronique Mesguiche, David R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

13

Randomized cross-over clinical trial to study potential pharmacokinetic interactions between cisplatin or carboplatin and etoposide

Huw D. Thomas, David J. Porter, Imke Bartelink, Joy R. Nobbs, Michael Cole, Suzie Elliott, David R. Newell, A. Hilary Calvert, Martin Highley, Alan V. Boddy

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

14

The clinical pharmacokinetics of the novel antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717)

Dawn L. Alison, David R. Newell, Christiana Sessa, Stephen J. Harland, Leigh I. Hart, Kenneth R. Harrap, A. Hilary Calvert

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1985

Language:

english

File:

PDF, 614 KB

english, 1985

15

The pharmacokinetics and toxicity of the anthrapyrazole anti-cancer drug CI-941 in the mouse: a guide for rational dose escalation in patients

Martin A. Graham, David R. Newell, Brenda J. Foster, A. Hilary Calvert

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1989

Language:

english

File:

PDF, 768 KB

english, 1989

16

Phase II trial of carboplatin (JM8) in treatment of patients with malignant mesothelioma

Edward K. Mbidde, Stephen J. Harland, A. Hilary Calvert, Ian E. Smith

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1986

Language:

english

File:

PDF, 228 KB

english, 1986

17

Carboplatin and etoposide pharmacokinetics in patients with testicular teratoma

David R. Newell, Rosalind A. Eeles, Lindsey A. Gumbrell, Francis E. Boxall, Alan Horwich, A. Hilary Calvert

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1989

Language:

english

File:

PDF, 624 KB

english, 1989

18

Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG)

Nicholas Pavlidis, Steinar Aamdal, Ahmad Awada, Hilary Calvert, Pierre Fumoleau, Roberto Sorio, Cees Punt, Jaap Verweij, Allan van Oosterom, Rudolf Morant, Jantien Wanders, Axel-R. Hanauske

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 80 KB

english, 2000

19

Pharmacokinetics of carboplatin administered in combination with the bradykinin agonist Cereport (RMP-7) for the treatment of brain tumours

Huw D. Thomas, Michael J. Lind, Judith Ford, Norman Bleehen, A. Hilary Calvert, Alan V. Boddy

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 104 KB

english, 2000

20

Pharmacological study of paclitaxel duration of infusion combined with GFR-based carboplatin in the treatment of ovarian cancer

Alan V. Boddy, Melanie J. Griffin, Julieann Sludden, Huw D. Thomas, Kevin Fishwick, James G. Wright, Ruth E. Plummer, Martin Highley, Hilary A. Calvert

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

21

Phase I study of weekly plitidepsin as 1-hour infusion combined with carboplatin in patients with advanced solid tumors or lymphomas

Ramón Salazar, Ruth Plummer, Ana Oaknin, Angela Robinson, Beatriz Pardo, Arturo Soto-Matos, Alejandro Yovine, Sergio Szyldergemajn, Alan Hilary Calvert

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 141 KB

english, 2011

22

Development of an assay for the estimation of N10-propargyl-5,8-dideazafolic acid polyglutamates in tumor cells

Ewa Sikora, David R. Newell, Ann L. Jackman, Alan J. Simmonds, Terence R. Jones, A.Hilary Calvert

Journal:

Analytical Biochemistry

Year:

1988

Language:

english

File:

PDF, 946 KB

english, 1988

23

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer

Sigalas, Iakovos, Calvert, A. Hilary, Anderson, John J., Neal, David E., Lunec, John

Journal:

Nature Medicine

Year:

1996

File:

PDF, 695 KB

1996

24

The Potential of PARP Inhibitors in Genetic Breast and Ovarian Cancers

Yvette Drew, Hilary Calvert

Journal:

Annals of the New York Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 243 KB

english, 2008

25

Resistance-Modifying Agents. 11.1 Pyrimido[5,4-d]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α1-Acid Glycoprotein

Curtin, Nicola J., Barlow, Hannah C., Bowman, Karen J., Calvert, A. Hilary, Davison, Richard, Golding, Bernard T., Huang, Bing, Loughlin, Peter J., Newell, David R., Smith, Peter G.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 324 KB

english, 2004

26

Bioequivalence assessment of etoposide phosphate and etoposide using pharmacodynamic and traditional pharmacokinetic parameters

Vanaja Mummaneni, Sanjeev Kaul, Linus N. Igwemezie, David R. Newell, David Porter, Huw Thomas, A. Hilary Calvert, Benjamin Winograd, Rashmi H. Barbhaiya

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1996

Language:

english

File:

PDF, 679 KB

english, 1996

27

Pemetrexed safety and dosing strategy

Clet Niyikiza, Axel-R Hanauske, James J. Rusthoven, A.Hilary Calvert, Robert Allen, Paolo Paoletti, Paul A. Bunn Jr

Journal:

Seminars in Oncology

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

28

Future directions in the development of pemetrexed

Hilary Calvert, Paul A. Bunn Jr

Journal:

Seminars in Oncology

Year:

2002

Language:

english

File:

PDF, 696 KB

english, 2002

29

Introduction

Paul A. Bunn Jr, Hilary Calvert

Journal:

Seminars in Oncology

Year:

2002

Language:

english

File:

PDF, 42 KB

english, 2002

30

Folate status and the safety profile of antifolates

Journal:

Seminars in Oncology

Year:

2002

Language:

english

File:

PDF, 73 KB

english, 2002

31

Pemetrexed (Alimta): A promising new agent for the treatment of breast cancer

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 73 KB

english, 2003

32

Resistance-Modifying Agents. 9.1 Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

White, Alex W., Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J., Griffin, Roger J., Hostomsky, Zdenek, Maegley, Karen, Newell, David R., Srinivasan, Sheila, Golding, Bernard T.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 315 KB

english, 2000

33

Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells

Robert C. Jackson, Ann L. Jackman, A.Hilary Calvert

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 899 KB

english, 1983

34

Modulation of anti-metabolite effects: Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, cb3717

Ann L. Jackman, Gordon A. Taylor, A.Hilary Calvert, Kenneth R. Harrap

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 779 KB

english, 1984

35

The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat

David R. Newell, Patrick M. O'Connor, A. Hilary Calvert, Kenneth R. Harrap

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 619 KB

english, 1986

36

Formation and retention and biological activity of N10-propargyl-5, 8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro

Ewa Sikora, Ann L. Jackman, David R. Newell, A.Hilary Calvert

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 1018 KB

english, 1988

37

The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

Ann L. Jackman, David R. Newell, William Gibson, Duncan I. Jodrell, Gordon A. Taylor, Joel A. Bishop, Leslie R. Hughes, A. Hilary Calvert

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 1009 KB

english, 1991

38

Intrathoracic lymphoma associated with atrial arrhythmias and atrioventricular conduction defects

Peter Mitchell-Heggs, Hilary Calvert

Journal:

British Journal of Diseases of the Chest

Year:

1978

Language:

english

File:

PDF, 234 KB

english, 1978

39

Design and conduct of phase II studies of targeted anticancer therapy: Recommendations from the task force on methodology for the development of innovative cancer therapies (MDICT)

Christopher M. Booth, A. Hilary Calvert, Giuseppe Giaccone, Marinus W. Lobbezoo, Elizabeth A. Eisenhauer, Lesley K. Seymour

Journal:

European Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 174 KB

english, 2008

40

Open-label, non-randomised, inter-individual dose escalation of ZK 304709 with the evaluation of safety, tolerability, pharmacokinetics, oral bioavailability and orientating efficacy after daily administration in patients with advanced cancer (7 d treatment and 14 d recovery)

Janet S. Graham, Ruth Plummer, Candice McCoy, Kristin Kowal, Herbert Wiesinger, Katharina Detjen, Hilary Calvert, Bertram Wiedenmann, Jim Cassidy

Journal:

European Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 152 KB

english, 2008

41

Phase 0 clinical trials: Recommendations from the task force on methodology for the development of innovative cancer therapies

Shivaani Kummar, James H. Doroshow, Joseph E. Tomaszewski, A. Hilary Calvert, Marinus Lobbezoo, Giuseppe Giaccone

Journal:

European Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 144 KB

english, 2009

42

A randomised, double-blind, phase II study of two doses of pemetrexed in the treatment of platinum-resistant, epithelial ovarian or primary peritoneal cancer

Ignace Vergote, Hilary Calvert, Marek Kania, Christopher Kaiser, Annamaria Hayden Zimmermann, Jalid Sehouli

Journal:

European Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 193 KB

english, 2009

43

Targeted agents: How to select the winners in preclinical and early clinical studies?

Rachel Goodwin, Giuseppe Giaccone, Hilary Calvert, Marinus Lobbezoo, Elizabeth A. Eisenhauer

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 218 KB

english, 2012

44

Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4- d ]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α 1 -Acid Glycoprotein

Saravanan, Kappusamy, Barlow, Hannah C., Barton, Marion, Calvert, A. Hilary, Golding, Bernard T., Newell, David R., Northen, Julian S., Curtin, Nicola J., Thomas, Huw D., Griffin, Roger J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

45

Novel Benzimidazole and Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose)polymerase*

ROGER J. GRIFFIN, SHEILA SRINIVASAN, ALEX W. WHITE, KAREN BOWMAN, A. HILARY CALVERT, NICOLA J. CURTIN, DAVID R. NEWELL, BERNARD T. GOLDING

Journal:

Journal of Pharmacy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 387 KB

english, 1996

46

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Arris, Christine E., Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J., Endicott, Jane A., Garman, Elspeth F., Gibson, Ashleigh E., Golding, Bernard T., Grant, Sharon, Griffin, Roger J., Jewsbur

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 542 KB

english, 2000

47

Good manners for the pharmaceutical industry

Hilary Calvert, Stan Kaye, Richard Osborne, Karol Sikora, Hilary Thomas

Journal:

Year:

1997

Language:

english

File:

PDF, 45 KB

english, 1997

48

Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogs

Thornton, Timothy J., Jones, Terence R., Jackman, Ann L., Flinn, Anthony, O'Connor, Breda M., Warner, Peter, Calvert, A. Hilary

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 900 KB

english, 1991

49

Resistance-Modifying Agents. 8. 1 Inhibition of O 6 -Alkylguanine-DNA Alkyltransferase by O 6 -Alkenyl-, O 6 -Cycloalkenyl-, and O 6 -(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O 6 -(1-Cyclopentenylmethyl)guanine

Griffin, Roger J., Arris, Christine E., Bleasdale, Christine, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J., Dalby, Christine, Kanugula, Sreenivas, Lembicz, Nicola K., Newell, David R., Pegg

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 215 KB

english, 2000

50

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

Marsham, Peter R., Hughes, Leslie R., Jackman, Ann L., Hayter, Anthony J., Oldfield, John, Wardleworth, J. Michael, Bishop, Joel A. M., O'Connor, Brigid M., Calvert, A. Hilary

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.53 MB

english, 1991